S.C. Code Ann. § 57-25-430
(a) No outdoor advertising sign shall be erected or maintained within three hundred feet of the nearest edge of the right-of-way and visible from the main-traveled way of the highway, except the following:
(d) No sign permitted under this section may be located in such a manner as to obscure or otherwise interfere with the effectiveness of an official traffic sign, signal or device, nor obstruct or interfere with the driver's view of approaching, merging or intersecting traffic; also, no such sign except on premises and FOR SALE or LEASE signs may be located within three hundred feet of any of the following which are adjacent to the highway in areas outside of incorporated municipalities or within one hundred feet on sections inside municipalities.