S.C. Code Ann. § 47-5-120
Whenever the county board of health or the county health department has reason to believe, or has been notified by the Department of Health and Environmental Control, that there is danger that rabies may spread within that county, such board or department shall serve public notice by publication in a newspaper of general circulation in such county, requiring the owners of pets and other animals to confine such pets or other animals for such period as may be necessary to prevent the spread of rabies in such county. And when it shall be deemed advisable in the interest of public safety, the Department of Health and Environmental Control may order the inoculation against rabies of all pets or other animals so confined, whether or not such animal has been previously inoculated under the provisions of this chapter, and the Department of Health and Environmental Control shall aid the county health department in the execution of such emergency inoculations.