S.C. Code Ann. § 23-3-660
A person whose DNA record has been included in the State DNA Database may request expungement on the grounds that the person's conviction or adjudication has been reversed, set aside, or vacated. SLED shall purge DNA and all other identifiable record information from the State Database and shall destroy the person's sample if SLED receives the person's written request for expungement and a certified copy of the court order reversing, setting aside, or vacating the conviction or adjudication and proof that the identity of the individual making the request is the person whose record is to be expunged. If the person has more than one entry in the State DNA Database, only the entry covered by the expungement request may be expunged.