S.C. Code Ann. § 15-7-100
The court may change the place of trial in the following cases:
(3) When the convenience of witnesses and the ends of justice would be promoted by the change.
When the place of trial is changed all other proceedings shall be had in the county to which the place of trial is changed, unless otherwise provided by the consent of the parties in writing duly filed or order of the court. And the papers shall be filed or transferred accordingly.