Specific deficiency - This application fails to comply with the requirements of 37 CFR 1.821 - 1.825. This application contains a "Sequence Listing" as a PDF file (37 CFR 1.821(c)(2) ) or as physical sheets of paper (37 CFR 1.821(c)(3) ). A copy of the "Sequence Listing" in computer readable form (CRF) has been submitted; however, the content of the CRF does not comply with one or more of the requirements of 37 CFR 1.822 through 1.824, as indicated in the "Error Report" that indicates the "Sequence Listing" could not be accepted. Refer to attachment or document "Computer Readable Form (CRF) for Sequence Listing – Defective" dated [1].

1. Required response – Applicant must provide:

   • A replacement "Sequence Listing" part of the disclosure, as described above in item 1); together with
2. • An amendment specifically directing its entry into the application in accordance with 37 CFR 1.825(b)(2);
3. • A statement that the "Sequence Listing" includes no new matter as required by 37 CFR 1.825(b)(5); and
4. • A statement that indicates support for the amendment in the application, as filed, as required by 37 CFR 1.825(b)(4).
5. • If the replacement "Sequence Listing" part of the disclosure is submitted according to item 1) a) or b) above, Applicant must also provide:
   1. o A substitute specification in compliance with 37 CFR 1.52, 1.121(b)(3) and 1.125 inserting the required incorporation-by-reference paragraph, consisting of:
      1. - A copy of the previously-submitted specification, with deletions shown with strikethrough or brackets and insertions shown with underlining (marked-up version);
      2. - A copy of the amended specification without markings (clean version); and
      3. - A statement that the substitute specification contains no new matter and
      4. - An amendment to the specification to remove the "Sequence Listing previously submitted as a PDF file (37 CFR 1.821(c)(2) ) or as physical sheets of paper (37 CFR 1.821(c)(3) )
6. • If the replacement "Sequence Listing" part of the disclosure is submitted according to item 1) c) or d) above, Applicant must also provide:
   1. o A CRF in accordance with 1.821(e)(1) or 1.821(e)(2) as required by 37 CFR 1.825(b)(6)(ii); and
   2. o Statement according to item 2) a) or b) above.

Examiner Note:

1. This form paragraph must be preceded by form paragraph 24.01.

2. This form paragraph should only be used for sequence listing non-compliance where a compliant sequence listing is not required for examination of the application.

3. This form paragraph should be used for an application where the CRF is defective.

4. In bracket 1, insert the date of the appropriate document.

5. This form paragraph may be followed by one or more deficiency form paragraphs.