RELATES TO:

KRS 230.215, 230.225, 230.240, 230.260, 230.265, 230.290, 230.320, 230.370

STATUTORY AUTHORITY:

KRS 230.215(2), 230.225, 230.240(2), 230.260, 230.320, 230.370

NECESSITY, FUNCTION, AND CONFORMITY:

KRS 230.215(2) authorizes the Kentucky Horse Racing and Gaming Corporation to promulgate administrative regulations prescribing conditions under which all legitimate horse racing and wagering thereon is conducted in Kentucky. KRS 230.240(2) requires the corporation to promulgate administrative regulations restricting or prohibiting the administration of drugs or stimulants or other improper acts to horses prior to the horse participating in a race. This administrative regulation establishes the withdrawal guidelines for permitted drugs, medications, and substances that may be administered to race horses competing in Kentucky.

1. Section 1. The Kentucky Horse Racing and Gaming Corporation Withdrawal Guidelines Thoroughbred; Standardbred; Quarter Horse, Appaloosa, and Arabian.

   1. (1) This administrative regulation shall provide certain mandatory treatment requirements, guidance, and advice on medication withdrawal intervals.
   2. (2) These withdrawal guidelines regarding furosemide shall not apply to two (2) year-old or stakes horses pursuant to 810 KAR 8:010, Section 6.

   3. (3)

      1. (a) Unless otherwise specified in these withdrawal guidelines, KAR Title 810, or KRS Chapter 230, the following withdrawal guidelines in this section are voluntary and advisory. The guidelines are recommendations based on current scientific knowledge that may change over time.
      2. (b) A licensee may present evidence of full compliance with these guidelines to the corporation and the stewards as a mitigating factor to be used in determining violations and penalties.
      3. (c) These withdrawal interval guidelines assume that administration of medications will be performed at doses that are not greater than the manufacturer's maximum recommended dosage, or the dosage recommended in this document. Medications administered at dosages above manufacturer's recommendations, in compounded formulations, or in combination with other medications or administration inside the withdrawal interval may result in test sample concentrations above threshold concentrations that could lead to positive test results and the imposition of penalties.
      4. (d) The time of administration of an orally administered substance, for the purposes of withdrawal interval, shall be considered to be the time of complete ingestion of the medication by the horse via eating or drinking.
      5. (e) For products containing multiple medications, the withdrawal time to be used should be no less than the longest identified for any of the individual constituent substances--even if that substance is not present in the highest concentration in the product.
      6. (f) Brand names of medications, where applicable, are listed in parentheses following the generic name of a drug.

   4. (4)

      1. (a) Withdrawal Guidelines. Furosemide shall be administered pursuant to 810 KAR 8:010.

      2. (b) The following substances may be administered or applied up to the scheduled paddock time of the race in which the horse is to compete:

         1. 1. Topical applications, such as liniments, leg paints, salves, and ointments, which may contain antibiotics or DMSO, but do not contain steroids, anesthetics, or any other prohibited substances.

         2. 2. The following substances may be administered up to twenty-four (24) hours prior to the scheduled post time of the race in which the horse is to compete as long as their use follows subsection (3) of this section:

            1. a. Antibiotics, except those containing prohibited drugs, such as Procaine;
            2. b. Antiprotozoals, such as ponazuril (Marquis), toltrazuril (Baycox), sulfamethoxazole/pyrimethamine (Daraprim);
            3. c. Antifungal agents, such as Griseofulvin and Ketoconazole;
            4. d. Certain inhalation agents that do not exhibit bronchodilator properties, such as cromolyn sodium (Intal), and acetylcysteine (Mucomyst);
            5. e. Cimetadine (Tagamet), orally at 20 mg/kg twice daily for 7 doses;
            6. f. Electrolytes, Vitamins, and Minerals, via IV, IM or oral administration;
            7. g. Any oral supplements or nutrients not containing drugs;
            8. h. Hyaluronic Acid (Legend), via IV administration;
            9. i. Misoprostol;
            10. j. Non-Androgenic Reproductive Hormones, such as HCG, Regumate and GnRH, in fillies and mares only;
            11. k. Omeprazole (Gastrogard), orally at 2.2 g once daily for 4 days;
            12. l. Polysulfated glycosaminoglycan (Adequan), via IM administration;
            13. m. Proprionibacterium acnes suspension (Eqstim), or comparable immunostimulants, excluding levamisole;
            14. n. Ranitidine (Zantac), orally at 8 mg/kg twice daily for 7 doses; and
            15. o. Sucralfate.

         3. 3. Non-steroidal anti-inflammatory drugs (NSAIDS):

            1. a. Elected NSAID: Only one of the following three NSAIDS may be administered up to the manufacturer's maximum labeled dosage until forty-eight (48) hours prior to the scheduled post time of the race in which the horse is to compete, as long as their use follows Section 1(3) of this administrative regulation and the requirements of 810 KAR 8:010.

               1. (i) Phenylbutazone (Butazolidin) 4.4 mg/kg, via IV administration only;
               2. (ii) Flunixin Meglumine (Banamine) 1.1 mg/kg, via IV administration only; and
               3. (iii) Ketoprofen (Ketofen) 2.2 mg/kg, via IV administration only.

            2. b. In accordance with the European Horserace Scientific Liaison Committee, the following withdrawal intervals shall be observed for all NSAIDS, except for those established in subparagraph 3.a. of this paragraph, for administration prior to the scheduled post time of the race in which the horse is to compete, as long as their use follows Section 1(3) of this administrative regulation:

               1. (i) Flunixin Meglumine (Banamine) 1.1 mg/kg, via IV administration: 6-day withdrawal interval;
               2. (ii) Phenylbutazone (Butazolidin) 4.4 mg/kg, via IV administration: 7-day withdrawal interval;
               3. (iii) Ketoprofen (Ketofen) 2.2 mg/kg, via IV administration: 4-day withdrawal interval;
               4. (iv) Diclofenac Sodium Topical (Surpass Cream), via a single, 5-inch application: 7- day withdrawal interval; and
               5. (v) Firocoxib (Equioxx) 0.1 mg/kg, via a single oral or IV dose, repeated daily administration: 15-day withdrawal interval from date of last administration.

   5. (5) The following substances have a forty-eight (48) hour withdrawal guidance prior to the scheduled post time of the race in which the horse is to compete as long as their use follows Section 1(3) of this administrative regulation:

      1. (a) Acepromazine (Promace), via IV administration at 0.05 mg/kg;
      2. (b) Butorphanol (Torbugesic), via IV administration at 0.1 mg/kg;
      3. (c) Cetirizine (Zyrtec), orally at 0.4 mg/kg twice daily for 5 doses; although it is recommended that ivermectin should not be administered within forty-eight (48) hours of a race if horse has been administered cetirizine;
      4. (d) Dantrolene (Dantrium), via oral administration at 500 mg total dose;
      5. (e) Detomidine (Dormosedan), via IV administration at 5 mg single dose;
      6. (f) DMSO via IV, oral, or topical administration up to 60 ml;
      7. (g) Glycopyrrolate (Robinol), via IV administration at 1 mg total dose;
      8. (h) Guaifenesin, orally at 2 g twice daily for 5 doses;
      9. (i) Methocarbamol (Robaxin-V), via single IV at 15 mg/kg;
      10. (j) Procaine penicillin, via IM administration at 17 mg/kg; and
      11. (k) Xylazine (Rompun), via IV administration at 200 mg single dose.

   6. (6) The following substances shall not be administered within forty-eight (48) hours of a race:

      1. (a) Beta-2 agonists by inhalation, such as terbutaline, salmeterol, and fenoterol;
      2. (b) Ergot alkaloids, such as Ergonovine and Methergine;
      3. (c) Ipratopium;
      4. (d) Isoxsuprine; and
      5. (e) Pentoxyphylline (Trental).

   7. (7) The following substances may be administered up to seventy-two (72) hours prior to the scheduled post time of the race in which the horse is to compete as long as their use follows Section 1(3) of this administrative regulation:

      1. (a) Albuterol (Proventil) via inhalation at 720 mcg;
      2. (b) Dexamethasone (Azium), via oral, IV, IM administration at 0.05 mg/kg. However, if another corticosteroid was administered systemically or intra-articularly, this withdrawal guidance shall not apply and a minimum five (5) day withdrawal is recommended;
      3. (c) Lidocaine, via subcutaneous administration at 200 mg total dose;
      4. (d) Mepivacaine (Carbocaine), via subcutaneous administration at 0.07 mg/kg; and
      5. (e) Romifidine (Sedivet), via IV administration at 50 mg.

   8. (8) The following substances may be administered up to ninety-six (96) hours prior to the scheduled post time of the race in which the horse is to compete as long as their use follows Section 1(3) of this administrative regulation:

      1. (a) Hydroxyzine (Atarax); and
      2. (b) Phenytoin (Dilantin).
   9. (9) Reserpine (Serpasil) may be administered up to seven (7) days prior to the scheduled post time of the race in which the horse is to compete as long as its use follows Section 1(3) of this administrative regulation.
   10. (10) The use of an extra-corporeal shock wave therapy or radial pulse wave therapy machine may be performed until ten (10) days prior to the scheduled post time of the race in which the horse is to compete, as long as its use complies with 810 KAR 8:010.
   11. (11) The following substance may be administered up to twenty-one (21) days prior to the scheduled post time of the race in which the horse is to compete, as long as its use follows Section 1(3) of this administrative regulation, and its use complies with 810 KAR 8:010, Section 10: Clenbuterol (Ventipulmin), orally up to 0.8 mcg/kg twice daily

   12. (12) Any horse that has been treated with therapeutic medications found in Section 1 of this administrative regulation may, at the trainer's request and expense, and on permission of a corporation veterinarian, have samples of blood or urine collected by the corporation veterinarian for analysis by the corporation laboratory prior to entry to race in the state of Kentucky.

       1. (a) As a condition of this elective testing, the trainer shall be required to disclose the date and time, dose, and route of administration of the substance for which clearance testing is requested.
       2. (b) A report from the corporation laboratory of a negative finding in this pre-race, elective testing shall not provide a safe harbor for the owner, trainer, veterinarian, or horse. A report from the corporation laboratory of a positive finding in a post-race sample shall be treated as a violation of KAR Title 810, even if there was a negative finding by the corporation laboratory in the clearance testing sample.

   13. (13) The following shall have a fourteen (14) day stand down period for intra-articular injection. Any IA corticosteroid injection within fourteen (14) days shall be a violation:

       1. (a) Betamethasone, via IA administration at 9 mg total dose in a single articular space. Withdrawal time should be increased for use of betamethasone products with a ratio of greater than 1:1 betamethasone acetate to betamethasone sodium phosphate. Intramuscular administration is associated with substantially longer withdrawal times.
       2. (b) Isoflupredone (Predef 2x), via IA administration at 20 mg in a single joint space or 10 mg subcutaneous.
       3. (c) Methyprednisolone (Depo-Medrol), via IA administration at a total dose of less than 100 mg in a single articular space. Intramuscular administration is associated with substantially longer withdrawal times and is not recommended, in accordance with the Racing Medication and Testing Consortium. Clearance testing is recommended in blood and urine prior to entry.
       4. (d) Triamcinolone acetonide (Vetalog), via IA administration at 9 mg total dose in a single articular space. Intramuscular administration is associated with substantially longer withdrawal times.
   14. (14) It is recommended that any horses receiving Fluphenazine (Prolixin) receive pre-race clearance testing.
   15. (15) Withdrawal Guidelines Chart: SubstanceBrand NameRecommended Minimum WithdrawalAdministration SpecificationsAcepromazinePromAce48 hours0.05 mg/kg via IV administrationAcetylcysteineMucomyst24 hoursInhalationAlbuterolProventil72 hours720 mcg via inhalationBeclomethasoneBeclovent24 hoursInhalation onlyButorphanolTorbugesic48 hours0.1 mg/kg via IV administrationCetirizineZyrtec48 hours0.4 mg/ml orally twice daily for 5 dosesCimetadineTagamet24 hours20 mg/kg orally twice daily for 7 dosesClenbuterolVentipulmin21 days0.8 mcg/kg orally (Pursuant to 810 KAR 8:010, Section 10, clenbuterol shall be prohibited unless the prescription is made for a specific horse based on a specific diagnosis. The veterinarian shall provide a copy of the treatment sheet to the Equine Medical Director or designee for review within twenty-four (24) hours of administration. A horse administered clenbuterol shall be placed on the veterinarian's list for at least twenty-one (21) days after the last administration. The horse shall meet all conditions for removal from the list, including negative blood and urine sampling.)Cromolyn sodiumIntal24 hoursInhalationDantroleneDantrium48 hours500 mg orallyDetomidineDormosedan48 hours5 mg via IV administrationDexamethasoneAzium72 hours IV PO, with no other corticosteroids administered. 5 days if other corticosteroids have been administered.IV, PO, IM, pursuant to the European Horserace Scientific Liaison Committee.DMSO 48 hoursTopical, IV, or oral administration up to 60 mlErgonovine 48 hoursNo dose specifiedFenoterol 48 hoursVia inhalation, no dose specifiedFurosemide (2-year-olds beginning in 2020; Stakes horses beginning in 2021)Salix24 hoursAdministration shall be prohibited at less than 24 hours, and limited to a maximum 500 mg single dose via IV administrationFurosemideSalix4 hours150-500 mg single IV dose administered by KHRC veterinarian. See 810 KAR 8:010, Section 6.Guaifenesin 48 hours2 g orally twice daily for 5 dosesGlycopyrrolateRobinol48 hours1 mgGriseofulvinFulvacin24 hoursNo dose specifiedHyaluronic AcidLegend24 hoursIV administration only; no dose specifiedHydroxyzineAtarax96 hoursNo dose specifiedIpratropium 48 hoursVia inhalation, no dose specifiedIsoxsuprineVasodilan48 hoursNo dose specifiedKetoconazoleNizoral24 hoursNo dose specifiedLidocaine 72 hours200 mg total dose SQMepivacaineCarbocaine72 hours0.07 mg/kg SQMethocarbamolRobaxin48 hours15 mg/kg single IVMethylergonovineMethergine48 hoursNo dose specifiedMisoprostolCytotec24 hoursNo dose specifiedOmeprazoleGastrogard24 hours2.2 g orally once daily for 4 daysOmeprazoleGastrogard24 hours2.2 g orally once daily for 4 daysPentoxyfyllineTrental48 hoursNo dose specifiedPhenytoinDilantin96 hoursNo dose specifiedPonazuril/Diclazuril/Sulfadiazine-PyrimethamineMarquis/Protazil24 hoursOralProcaine Penicillin 48 hours17 mg/kg IM (Procaine penicillin treatments shall be reported to the stewards no later than twenty-four (24) hours after the last injection is administered. Horses so treated may be required to be under corporation-approved, continuous surveillance for the six-hour interval prior to the post time for the race in which the horse is entered. The owner of the horse shall be responsible for all costs associated with the surveillance. Prospective surveillance arrangements shall be submitted to the stewards no later than close of business on the day of entry.)PSGAGAdequan24 hoursVia IM administrationRanitidineZantac24 hours8 mg/kg orally twice daily for 7 dosesReserpineSerpasil7 daysNo dose specifiedRomifidineSedivet72 hours50 mg via IV administrationSalmeterol 48 hoursVia inhalation, no dose specifiedSucralfateCarafate24 hoursNo dose specifiedTerbutaline 48 hoursNo dose specifiedXylazineRompun48 hours200 mg via IV administration
   16. (16) NSAID withdrawal guidelines chart: SubstanceBrand NameRecommended Minimum WithdrawalAdministration SpecificationsPhenylbutazoneButazolidin48 hours—single elected NSAID. If this is not the single elected NSAID, then 7 days, pursuant to the European Horserace Scientific Liaison Committee.4.4 mg/kg via IV administrationFlunixinBanamine48 hours—single elected NSAID. If this is not the single elected NSAID, then 6 days, pursuant to the European Horserace Scientific Liaison Committee.1.1 mg/kg via IV administrationKetoprofenKetofen48 hours—single elected NSAID, If this is not the single elected NSAID, then 4 days, pursuant to the European Horserace Scientific Liaison Committee.2.2 mg/kg via IV administrationDiclofenacSurpass7 days, pursuant to the European Horserace Scientific Liaison Committee.5 inch ribbon of Surpass every 12 hours to one siteFirocoxibEquioxx15 days, pursuant to the European Horserace Scientific Liaison Committee.0.1 mg/kg once daily for 4 days
   17. (17) Miscellaneous withdrawal guidelines chart: SubstanceBrand NameRecommended Minimum WithdrawalAdministration SpecificationsAnthemintics (except thiazide products 72 hours Non-androgenic reproductive hormonesIncluding HCG, Regumate, GnRH, in fillies and mares only24 hours Proprionibacterium acnes suspension or comparable immunostimulants 24 hours Electrolytes, vitamins, minerals 24 hoursVia IV or IM administrationAntibiotics 24 hours Any injectable other than furosemide 24 hours810 KAR 8:010 specifically prohibits any injections at less than 24 hours to post time for any substance.Intra-articular injections, other than corticosteroids 72 hours

2. Section 2.

   1. (1) Available Threshold Levels Associated to KHRC Withdrawal Guidelines: SubstanceThresholdAcepromazine10 nanograms per ml in urine of hydroxyethylpromazine sulfoxide (HEPS)Albuterol1 nanogram per ml in urineBoldenoneMale horses other than Geldings15 nanograms per ml in urine of boldenone, free and conjugated –OR– 25 picograms per ml in serum or plasma of boldenone, freeBoldenoneGeldings and femaleHorses1 nanogram per mil in urine of boldenone, free and conjugatedButorphanol2 nanograms per ml in serum or plasma of butorphanol, free –OR– 300 nanograms per ml in urine of total butorphanolCetirizine6 nanograms per ml in serum or plasmaCimetadine400 nanograms per ml in serum or plasmaClenbuterolLimit of detection in both urine and bloodDantrolene0.1 nanograms per ml of serum or plasma of 5-OH dantroleneDetomidine2 nanogram per ml in urine of carboxydetomidine –OR– 1 nanogram per ml of detomidine in serum or plasmaDiclofenac5 nanograms per ml in serum or plasmaDMSO10 micrograms per ml in serum or plasmaFirocoxib20 nanograms per ml in serum or plasmaFlunixin5 nanograms per ml in serum or plasmaFurosemideFor horses eligible to race on furosemide, 100 nanograms per ml in serum or plasma –AND– Urine specific gravity of less than 1.010 –OR– 1 nanogram per ml in serum or plasma for 2-year-olds beginning in 2020 or stakes horses beginning in 2021, see 810 KAR 8:010Glycopyrrolate3 picograms per ml in serum or plasmaGuaifenesin12 nanograms per ml in serum or plasmaKetoprofen2 nanograms per ml of serum or plasmaLidocaine20 picograms per ml in serum or plasma of Total 3-OH-lidocaineMepivacaine10 nanograms per ml in urine of OH-mepivicaine –OR– Limit of detection in serum or plasmaMethocarbamol1 nanogram per ml in serum or plasmaMethylprednisolone100 picograms per ml in serum or plasmaNandrolone (Male horses other than geldings)45 nanograms per ml in urine of 5α-estrane-3β, 17α-diol –OR– In urine a ratio of 5α estrane-3β, 17 α-diol to 5α estrene-3β, 17 α-diol of > 1:1Nandrolone (Geldings and female horses)1 nanogram per ml in urine of nandrolone, free and conjugated –OR– 50 picograms per ml of procaine in blood, serum, or plasma of nandrolone, freeOmeprazole10 nanograms per ml omeprazole sulfide in serum or plasmaPhenylbutazone0.3 micrograms per ml in serum or plasmaPrednisolone10 nanograms per ml free Prednisolone in urineProcaine Penicillin (Horses reported to have been treated with procaine penicillin)25 nanograms per ml of procaine in serum or plasma (Procaine penicillin treatments shall be reported to the stewards no later than 24 hours after the last injection is administered. Horses so treated may be required to be under KHRC approved, continuous surveillance for the six hour interval prior to the post time for the race in which the horse is entered. The owner of the horse shall be responsible for all costs associated with the surveillance. Prospective surveillance arrangements shall be submitted to the stewards no later than close of business on the day of entry.)Procaine Penicillin (Horses not reported to have been treated with procaine penicillin)Limit of detection for procaine in serum or plasma (Procaine penicillin treatments shall be reported to the stewards no later than 24 hours after the last injection is administered. Horses so treated may be required to be under KHRC approved, continuous surveillance for the six hour interval prior to the post time for the race in which the horse is entered. The owner of the horse shall be responsible for all costs associated with the surveillance. Prospective surveillance arrangements shall be submitted to the stewards no later than close of business on the day of entry.)Ranitidine40 nanograms per ml in serum or plasmaTestosterone (Geldings)20 nanograms per ml in urine of testosterone, free and conjugated –OR– 25 picograms per ml in serum or plasma of testosterone, freeTestosterone (Female horses (unless in foal))55 nanograms per ml in urine of testosterone, free and conjugated –OR– 100 picograms per ml in serum or plasma of testosterone, freeXylazine200 picograms per ml in serum or plasma
   2. (2) All other NSAIDs not listed on the withdrawal guidelines shall have a threshold set at limit of detection in serum or plasma.

History

(47 Ky.R. 2188; 48 Ky.R. 35; eff. 10-5-2021; 47 Ky.R. 2188; 48 Ky.R. 35, 1933; eff. 5-31-2022; TAm eff. 7-1-2024.)