N.Y. Comp. Codes R. & Regs. tit. 6, § 661.6
(a) No person shall undertake any new regulated activity on any tidal wetland or on any adjacent area except in compliance with the following development restrictions:
(5) The minimum lot area for any principal building constructed within the area regulated by this Part, which minimum lot area shall include any wetland portion and any adjacent area portion of such lot, shall be as follows:
(ii) 40,000 square feet where such principal building will not be served by a public or community sewage disposal system.
Notwithstanding any other provision of this Part, the requirements of this paragraph for buildings to be served by a public or community sewage disposal system shall not be applicable within the boundaries of the city of New York.