Specific deficiency - This application fails to comply with the requirements of 37 CFR 1.821 - 1.825 because the "Sequence Listing" part of the disclosure submitted as a PDF file (37 CFR 1.821(c)(2) ) or on physical sheets of paper (37 CFR 1.821(c)(3) )is not the same as the CRF of the "Sequence Listing" as required by 37 CFR 1.821(e)(1)(ii) or 1.821(e)(2)(ii).

Required response - Applicant must provide:

1. • A replacement "Sequence Listing" as described above in items 1) c) or d) in accordance with37 CFR 1.825(b)(1)(ii) or (iii); as well as
2. • An amendment specifically directing its entry into the application as required by 37 CFR 1.825(b)(2)(ii);
3. • A statement that identified the locations of any deletions, replacements or additions to the "Sequence Listing" as required by 37 CFR 1.825(b)(3);
4. • A statement that the "Sequence Listing" added by amendment includes no new matter as required by 37 CFR 1.825(b)(5);
5. • A statement that indicates support for the amendment in the application, as filed, as required by 37 CFR 1.825(b)(4); and
6. • A statement that the content of the previously-filed CRF is identical to the "Sequence Listing" part of the disclosure added by amendment as required by 37 CFR 1.825(b)(7), where provided under item 1) c) or d) (note that where a "Sequence Listing" part of the disclosure is provided under item 1) a) or b), the text file will also serve as the CRF, and the statement of identity is not required);

OR

1. • A CRF as required by 37 CFR 1.821(e)(1) or 1.821(e)(2); and
2. • A statement that the content of the CRF is identical to the "Sequence Listing" part of the disclosure previously submitted as a PDF file (37 CFR 1.821(c)(2) ) or on physical sheets of paper (37 CFR 1.821(c)(3) ), as required by 37 CFR 1.821(e)(1)(ii) or 1.821(e)(2)(ii).

Examiner Note:

1. This form paragraph must be preceded by 24.01.

2. This form paragraph should only be used for sequence listing non-compliance where a compliant sequence listing is not required for examination of the application.

3. This form paragraph should be used for an application in which the "Sequence Listing" part of the disclosure as required by 37 CFR 1.821(c) is not the same as the CRF as required by 37 CFR 1.821(e).

4. This form paragraph may be followed by one or more deficiency form paragraphs.