1. a) A diagnosis of a birth defect, made prenatally or by two years of age;
2. b) A gestational age of less than 31 completed weeks (ICD-10-CM P07.21-P07.33);
3. c) A diagnosis of fetal alcohol syndrome (ICD-10-CM Q86.0);
4. d) A fetal or neonatal death;

5. e) Substance Use

   1. 1) Prenatal maternal, post-natal infant or post-natal maternal positive toxicology for any controlled substance (except drugs administered during labor and delivery);
   2. 2) a maternal admission to illicit drug use, or cannabis use during the pregnancy that led to the delivery of this infant; or
   3. 3) signs of drug toxicity or withdrawal; or
6. f) A diagnosis of one of the following conditions made prior to discharge from the newborn hospitalization:

7. 1) Serious infections:

   1. A) Prenatal exposure to syphilis (ICD-10-CM Z20.2) or a diagnosis of congenital syphilis (ICD-10-CM A50.01-A53.9);
8. B) Prenatal exposure to hepatitis B or hepatitis C (ICD-10-CM Z20.2) or a diagnosis of hepatitis B or hepatitis C (ICD-10-CM P35.3);
9. C) Prenatal exposure to chlamydia (ICD-10-CM Z20.2) or a diagnosis of a chlamydial infection ICD-10-CM A74.89, A74.9, or P23.1);
10. D) Prenatal exposure to herpes (ICD-10-CM Z20.2) or a diagnosis of congenital herpes (ICD-10-CM P35.2);
11. E) Group B streptococcus (ICD-10-CM J15.3 or P36.0);
12. F) Gonococcal conjunctivitis (neonatorum) (ICD-10-CM P39.1);
13. G) Congenital listeriosis (ICD-10-CM P37.2);
14. H) Congenital rubella (ICD-10-CM P35.0);
15. I) Congenital cytomegalovirus (ICD-10-CM P35.1);
16. J) Tetanus neonatorum (ICD-10-CM A33);
17. K) Septicemia of the newborn ICD-10-CM P36.0-P36.9);
18. L) Prenatal exposure to human immunodeficiency virus (ICD-10-CM Z20.6); or
19. M) Other congenital infections (ICD-10-CM P35.8, P35.9 or P37.0-P37.9).

20. 2) Endocrine, metabolic or immune disorder:

    1. A) Hypothyroidism (ICD-10-CM E03.0-E03.9);
    2. B) Adrenogenital syndrome (ICD-10-CM E25.0-E25.9);
    3. C) Inborn errors of metabolism (- ICD-10-CM E70.0-E79.9);
    4. D) Cystic fibrosis (ICD-10-CM E84.0-E84.9); or
    5. E) Immune deficiency disorder (ICD-10-CM D80.0-D81.9).

    6. 3) Blood disorder:

       1. A) Leukemia (ICD-10-CM C91.0-C95.92);
       2. B) Hereditary hemolytic anemias (ICD-10-CM D58.0-D58.9);
       3. C) Constitutional aplastic anemia (ICD-10-CM D61.0-D61.09); or
       4. D) Coagulation defects (ICD-10-CM D65-D68.9).

21. 4) Other conditions:

    1. A) Neurofibromatosis (ICD-10-CM Q85.0-Q85.9);
    2. B) Cerebral lipidoses ICD-10-CM E75.4);
    3. C) Retinopathy of prematurity (ICD-10-CM H35.1-H35.17);
    4. D) Chorioretinitis (ICD-10-CM H30.00-H30.93);
    5. E) Strabismus (ICD-10-CM H50.00-H50.9);
    6. F) Endocardial fibroelastosis (ICD-10-CM I42.4);
    7. G) Occlusion of cerebral arteries (ICD-10-CM I63.30-I63.59 or I66.0-I66.9);
    8. H) Bronchopulmonary dysplasia (ICD-10-CM P27.1);
    9. I) Intrauterine growth retardation ICD-10-CM P05.0-P05.9);
    10. J) Intraventricular hemorrhage grade III (ICD-10-CM P52.21);
    11. K) Intraventricular hemorrhage grade IV ICD-10-CM P52.22);
    12. L) Seizures (ICD-10-CM P90);
    13. M) Other conditions leading to more than 72 hours on a ventilator (ICD-10-CM Z99.11);
    14. N) Conditions leading to extracorporeal membrane oxygenation (ECMO) (ICD-10-CM Z92.81)
    15. O) Erb's Palsy (ICD-10-CM P14.0)

    16. P) Hypoxic ischemic encephalopathy leading to cooling treatment (ICD-10-CM P91.63)

        AGENCY NOTE: The products of induced abortions shall not be reported to APORS.

An adverse pregnancy outcome for an infant consists of one or more of the following case criterion:

(Source: Amended at 46 Ill. Reg. 2971, effective February 1, 2022)