Fla. Admin. Code R. 75-6.011
(4) The presence of more than one Non Steroidal Anti-Inflammatory Drug (NSAID) constitutes an NSAID stacking violation under the following conditions:
(a) A Class 1 NSAID Stacking Violation (Penalty Class B) occurs when:
1. Two non-steroidal anti-inflammatory drugs are found at individual levels determined to exceed the following restrictions:
a. Diclofenac – 5 nanograms per milliliter of plasma or serum;
b. Firocoxib – 20 nanograms per milliliter of plasma or serum;
c. Flunixin – 20 nanograms per milliliter of plasma or serum;
d. Ketoprofen – 2 nanograms per milliliter of plasma or serum;
e. Phenylbutazone – 2 micrograms per milliliter of plasma or serum; or
f. All other non-steroidal anti-inflammatory drugs – any and all findings above zero.
2. Three or more non-steroidal anti-inflammatory drugs are found at individual levels determined to exceed the following restrictions:
a. Diclofenac – 5 nanograms per milliliter of plasma or serum;
b. Firocoxib – 20 nanograms per milliliter of plasma or serum;
c. Flunixin – 3 nanograms per milliliter of plasma or serum;
d. Ketoprofen – 1 nanograms per milliliter of plasma or serum;
e. Phenylbutazone – 0.3 micrograms per milliliter of plasma or serum; or
f. All other non-steroidal anti-inflammatory drugs – any and all findings above zero.
(b) A Class 2 NSAID Stacking Violation (Penalty Class C) occurs when:
1. Any one substance noted in Subsection (a)1. above is found in excess of the restrictions contained therein in combination with any one of the following substances at levels below the restrictions so noted but in excess of the following levels:
a. Flunixin – 3.0 nanograms per milliliter of plasma or serum;
b. Ketoprofen – 1 nanogram per milliliter of plasma or serum; or
c. Phenylbutazone – 0.3 micrograms per milliliter of plasma or serum;
(c) A Class 3 NSAID Stacking Violation (Penalty Class C, fines only) occurs when:
1. Any combination of two of the following non-steroidal anti-inflammatory drugs are found at or below the restrictions in subparagraphs (a)1.a.-e. above but in excess of the noted restrictions:
a. Flunixin – 3 nanograms per milliliter of plasma or serum;
b. Ketoprofen – 1 nanogram per milliliter of plasma or serum; or
c. Phenylbutazone – 0.3 micrograms per milliliter of plasma or serum.
(5) The Division shall consider the following mitigating or aggravating factors to deviate from the penalties provided by the Classification and Penalty Guidelines:
Rulemaking Authority 550.0251(3), 550.2415(7), (12) FS. Law Implemented 550.0251, 550.2415 FS. History–New 1-5-98, Amended 2-8-01, 3-4-07, 6-26-11, 1-10-16, 9-5-18, 8-29-19, Formerly 61D-6.011.