(a) Research institutions that conduct USDA-funded extramural research must promptly notify the ARIO should the institution become aware during an inquiry or investigation that:

1. (1) Public health or safety is at risk;
2. (2) The resources, reputation, or other interests of USDA are in need of protection;
3. (3) Research activities should be suspended;
4. (4) Federal action may be needed to protect the interest of a subject of the investigation or of others potentially affected;
5. (5) A premature public disclosure of the inquiry into or investigation of the allegation may compromise the process;
6. (6) The scientific community or the public should be informed; or
7. (7) There is reasonable indication of possible violations of civil or criminal law.