(d) For purposes of this section, the following terms have the following meanings:

1. (1) “Medically significant” means that a physician and surgeon has made a clinical determination that may include, but is not limited to, any of the following:

   1. (A) The treatment or medication is contraindicated or is likely, or expected, to cause an adverse reaction or physical or mental harm to the qualified patient if administered or used in conjunction with THC or medical cannabis, based on the known clinical characteristics of the patient and the known characteristics and history of the patient’s treatment or medication regimen.
   2. (B) The treatment or medication is expected to be ineffective based on the known clinical characteristics of the qualified patient and the known characteristics and history of the patient’s treatment or medication regimen.

   3. (C) The treatment or medication, when administered or used in conjunction with THC or medical cannabis, is not clinically appropriate for the qualified patient because the treatment or medication is expected to do any of the following, as determined by a physician and surgeon:

      1. (i) Worsen a comorbid condition.
      2. (ii) Decrease the capacity to maintain a reasonable functional ability in performing daily activities.
      3. (iii) Pose a significant barrier to adherence to, or compliance with, the qualified patient’s drug regimen or plan of care.
   4. (D) Any other clinically or medically relevant determination.
2. (2) “Qualified patient” has the same meaning as defined in Section 11362.7 of the Health and Safety Code.