OPINION OF THE COURT
Plaintiffs Susan Cohn and Walter R. Cohn, husband and wife, appeal from the final' summary judgment of the district court dismissing their complaint as untimely. Plaintiffs are residents of New Jersey; defendant G.D. Searle & Co. (Searle) is a Delaware corporation whose principal place of business is in Illinois. The district court’s jurisdiction over this case was grounded in diversity, 28 U.S.C. § 1332 (1982). We have appellate jurisdiction under 28 U.S.C. § 1291 (1982).
I.
The serpentine course of this litigation may be adequately charted from the five published opinions it has generated, 1 and there is no need to do more here than briefly note its highlights.
Plaintiffs brought suit in 1974 in the Superior Court of New Jersey. The complaint alleged that Susan Cohn suffered a stroke in 1963 that was caused by her use of the oral contraceptive Enovid, manufactured by Searle. Liability was premised on various state-law tort theories.
After removing the case to federal court, Searle moved for summary judgment on the ground that the suit was untimely under New Jersey’s two-year statute of limitations for tort actions, N.J.Stat.Ann. 2A.-14-2 (West 1969). Plaintiffs argued in response that the action was timely because N.J.Stat.Ann. 2A:14-22 (West 1969) (the tolling statute), tolled the statute of limitations. 2 The tolling statute provides that the statute of limitations is tolled in any action against a foreign corporation not “represented” in New Jersey by an agent for service of process, for as long as the defendant remains unrepresented. Plaintiffs argued — and all parties concede here — that Searle was unrepresented in New Jersey at all relevant times.
Defendant responded, inter alia, by ar- • guing that the tolling statute violated the Equal Protection and Due Process clauses of the United States Constitution. The district court accepted Searle’s equal protection argument and dismissed the complaint as time-barred. 3
*462 This court reversed on appeal, holding that the statute violated neither equal protection nor due process. 4 Although Searle’s brief before this court also attacked the tolling statute on Commerce Clause grounds, our opinion did not address that issue.
The Supreme Court, on certiorari, affirmed this court’s equal protection and due process holdings, but remanded for further consideration of Searle’s Commerce Clause claims. The Court declined to reach that issue, first, because it had not been addressed here or in the district court, and second, because of a perceived ambiguity as to the manner in which a foreign corporation could become “represented” within the meaning of the tolling statute. We in turn remanded to the district court to consider those issues.
Following our remand, but before the district court could issue its decision, the Supreme Court of New Jersey decided
Coons v. American Honda Motor Co.,
Subsequently, on rehearing, the court held that its invalidation of the tolling statute would not be accorded retroactive effect
5
; thus, “the statute of limitations as to foreign, unrepresented corporations commences to run as of” August 3, 1983, the date of the
Coons I
decision.
Coons v. American Honda Motor Co.,
After the New Jersey Supreme Court handed down its decision in Coons II, Searle renewed its summary judgment motion in the district court to dismiss the complaint as untimely, again arguing that the tolling statute violated the Commerce Clause. Plaintiffs apparently did not contend, at least in their briefs, that the tolling statute was consistent with the Commerce Clause, but argued instead — as they do here — that the holding in Coons II that the statute was only invalid prospectively was binding on the federal district court as an interpretation of state law. Alternatively, they argued that federal retroactivity principles dictated the same result reached in *463 Coons II. The district court granted Searle’s motion and dismissed the complaint. It held, first, that the tolling statute violated the Commerce Clause. Second, it rejected plaintiffs’ contention that it was bound by Coons II to apply its Commerce Clause holding nonretroactively, and, applying federal retroactivity principles, held that retroactive application was proper. This appeal followed.
II.
Plaintiffs reiterate their contention that under
Erie R. Co. v. Tompkins, 304
U.S. 64,
III.
We have not been asked to consider the correctness of the district court’s holding that the tolling statute violates the Commerce Clause, and consequently we do not reach that question. 6 Instead, we will assume without deciding that it was answered correctly by the district court. Thus, the only issue before us is whether the district court correctly resolved the secondary matter of retroactivity. Our standard of review is plenary.
In
Chevron Oil Co. v. Huson,
First, the decision to be applied nonretroactively must establish a new principle of law, either by overruling clear past precedent on which litigants may have relied, or by deciding an issue of first impression whose resolution was not clearly foreshadowed. Second, it has been stressed that “we must ... weigh the merits and demerits in each case by looking to the prior history of the rule in question, its purpose and effect, and whether retrospective application would further or retard its operation.” Finally, we have weighed the inequity imposed by retroactive application, for “[w]here a decision of this Court could produce substantial inequitable results if applied retroactively, there is ample basis in our cases for avoiding the ‘injustice or hardship’ by a holding of nonretroactivity.”
As noted in
Coons I,
Nor were the Commerce Clause principles involved so clear as to make the invalidity of the tolling statute a foregone conclusion. Searle stresses the well-settled precedents on which the
Coons I
court, and the district court here, relied.
See Alien-berg Cotton Co. v. Pittman,
We do not suggest that any decision that extends prior case law creates a “new principle of law” within the meaning of Chevron. What is crucial here is the presence of a duly-enacted, and therefore presumptively legitimate, statute on which citizens are normally entitled to rely. We cannot say that such reliance is unreasonable where the statute’s constitutionality has never been judicially questioned and where the reach of the constitutional principles involved is as uncertain as here. Thus, the first Chevron factor points to nonretroactivity.
The second
Chevron
factor requires us to consider whether retroactive invalidation of the statute will “further or retard [the] operation” of the Commerce Clause principles invoked in
Coons I.
The district court reasoned in this regard: “The purpose of the constitutional rule which governs this case is to free interstate commerce from the burdens which might be imposed by the individual states through which that com
*465
merce flows. Retroactive application of
Coons I
furthers that objective; prospective application defeats it.”
Assuming arguendo that the district court correctly stated the purpose of the Commerce Clause rule in this case, we think the burden on interstate commerce that it perceived might result from nonretroactive application of that rule is largely illusory. Certainly, any inhibiting effect the statute might have had on foreign corporations and others contemplating doing buisness in New Jersey vanishes once the statute is invalidated, whether or not that invalidation is retroactive. Moreover, had there been no tolling statute, the probability is that the Cohns and most other plaintiffs similarly situated would have filed suit within the two-year statutory period. Although it is possible that prospective invalidation will permit maintenance of some suits that would not have been timely filed absent the tolling statute, we do not think that this slight marginal burden, if any, does violence to the Commerce Clause. 8
Finally, equitable considerations also point to nonretroactive application. As in
Chevron,
“[i]t would ... produce the most ‘substantial inequitable results’ ... to hold that [plaintiff] ‘slept on his rights’ at a time when he could not have known the time limitation that the law imposed upon him____ [Nonretroactive application simply preserves his right to a day in court.”
IV.
Searle argues, however, that the
Chevron
balancing test is inappropriate here. Citing
United States v. U.S. Coin & Currency,
In
Marino v. Bowers,
Nor do the two cases cited by defendant persuade us to carve out an exception to Chevron in this case. U.S. Coin & Currency holds merely that where the Constitution is held to immunize certain conduct from criminal punishment, as under the self-incrimination clause of the Fifth Amendment, such a holding necessarily operates retroactively. That principle has no applicability here.
Cathedral Academy
is also inapposite. That case arose out of a New York statute (ch. 138) authorizing the use of state funds to reimburse private schools, including sectarian schools, for certain educational services. After a three-judge court held that ch. 138 violated the Establishment Clause and enjoined any further payments under it, the state legislature enacted a second statute (ch. 996) authorizing reimbursement for services performed in reliance on ch. 138 before its invalidation. In
Cathedral Academy,
the Supreme Court held that payments under ch. 996 also violated the Establishment Clause. The Court noted that the statute was enacted in clear violation of the district court’s decree, but held that the dispositive fact was that payments under ch. 996, like those under ch. 138, “will of necessity either have the primary effect of aiding religion, ... or will result in excessive state involvement in religious affairs.”
Whatever
Cathedral Academy
may teach us about retroactivity in the First Amendment context,
9
we are convinced that the decision does not preclude application of the
Chevron
retroactivity test where the retroactivity issue arises under the Commerce Clause. The balancing of state and national interests appropriate under the Commerce Clause,
see, e.g., Pike v. Bruce Church, Inc.,
V.
Finally, Searle argues that, even if the invalidation of the tolling statute is to be given general nonretroactive effect, we must nevertheless give it the benefit of the tolling statute’s invalidation in order to avoid rendering an advisory opinion and to give it the fruit of its efforts to change the law.
We have previously rejected the view that Article III does not permit a federal court to declare a new rule of law to be applied purely prospectively.
Ettinger v. Central Penn National Bank,
It does not follow, however, that application of the new legal principle to the liti
*467
gants is appropriate under all circumstances, regardless of any other considerations. In
England v. State Board of Medical Examiners,
VI.
We hold, therefore, that the district court erred in applying retroactively its holding that the New Jersey tolling statute violated the Commerce Clause. We reiterate that we express no view as to the constitutionality vel non of the tolling statute. The judgment of the district court will be vacated and the case remanded for further proceedings consistent with this opinion.
Notes
.
Cohn v. G.D. Searle & Co.,
. The tolling statute reads in relevant part:
"If any person against whom there is any of the causes of action specified in sections 2A:14-1 to 2A:14-5 and 2A:14-8 ... is not a resident of this state when such cause of action accrues____or if any corporation ... not organized under the laws of this state, against whom there is such a cause of action, is not represented in this state by any person or officer upon whom summons or other original process may be served, when such a cause of action accrues or at any time before the expiration of the times so limited, the time or times during which such person ... is not residing within this state or such corporation ... is not so represented within this state shall not be computed as part of the periods of time within which such an action is required to be brought commenced by the section. The person entitled to any such action may commence the same after the accrual of the cause therefor, within the period of time limited therefor by such section, exclusive of such time or times of nonresidence or nonrepresentation."
. In a separate, unreported opinion, the district court found that plaintiffs became aware of the possible link between Enovid and Susan Cohn’s stroke no later than 1970. Thus, under New
*462
Jersey’s discovery rule, the cause of action accrued at that time, and the statute of limitations ran out two years later.
See Lopez v. Swyer,
. We affirmed the district court’s statutory holding that Searle was “unrepresented" in New Jersey between 1963 and 1974, and was thus subject to the tolling statute. Following
Velmohos v. Maren Engineering Corp.,
. To avoid terminological confusion, the following definitions are in order. "Retroactive” describes judgments applicable in all cases, regardless of when the cause of action arose or the case was litigated. "Nonretroactive” judgments are those that apply the "new” law to the parties before the court, but the "old” law to parties to whom some critical event (e.g., the accrual of a cause of action) occurred before the date of the decision. "Prospective" judgments are equivalent to nonretroactive ones, except that the old law is applied even to the parties before the court.
See Marino v. Bowers,
. Appellant's initial brief did not challenge the district court’s Commerce Clause holding in either its statement of issues or its argument. Fed.R.App.P. 28(a) requires appellants to include in their initial brief “[a] statement of the issues presented for review," and it is well settled that courts of appeal will not consider issues not raised in the initial brief.
See 9
J. Moore,
Moore’s Federal Practice
fl 228.02[2. — 1]. While this rule has been relaxed on occasion,
e.g. Consumers Union of U.S., Inc. v. Federal Power Comm’n,
. The parties have argued at length about whether
United States v. Johnson,
. The New Jersey Supreme Court has held that, even where the claim is timely under the tolling statute, “[i]f a plaintiffs delay is inexcusable and has resulted in prejudice to the defendant, the latter may raise the equitable defense of laches to bar the claim.”
Velmohos v. Maren Engineering Corp.,
. Neither the Supreme Court nor the lower court in Cathedral Academy cited Chevron or discussed the retroactivity doctrine.
