Dow Chemical Co. (“Dow”) appeals a jury verdict in favor of plaintiffs finding Dow liable in the death of James Greenhill. We affirm.
I.
FACTS AND PROCEEDINGS BELOW
In 1976 and 1977, James Greenhill was seasonally employed by the United States Forest Service in Oregon. Although primarily a fire fighter, he occasionally participated in a weed control project called “hack and squirt.” This project required Greenhill to apply herbicides manufactured by Dow, exposing him to 2,4-dichlarophe-noxyacetic acid (2,4-D). Greenhill’s exposure to 2,4-D ceased in 1978 when he was transferred to another park. A year later, Greenhill was diagnosed with Hodgkin's disease. He died seven years later.
Greenhill’s surviving spouse, son, and parents sued Dow in the Eastern District of Texas. 1 The case was transferred to the “Agent Orange” products liability action in the Eastern District of New York. After settlement of that case in 1986, Greenhill’s action against Dow for the exposure to 2,4-D was returned to Texas.
The case was tried in November and December, 1987. A jury awarded the plaintiffs $1.5 million in damages. Dow appeals.
II.
JURISDICTION
The district court had jurisdiction under 28 U.S.C. § 1332. This court’s jurisdiction rests on § 1291.
III.
DISCUSSION
A number of issues of various weights are raised by this appeal. It is uncertain whether this number could have been reduced by a more crisp and orderly process than appears to have been employed in this case. It is likely, however, that a more crisp and orderly process would have framed the issues more precisely. The difficulty is that while such a process would have simplified our task, it is by no means clear which party would have been favored or disfavored thereby. We now turn to the issues.
A. Notice of Appeal
Plaintiffs seek to narrow the issues properly before us by asserting that Dow can appeal only the court’s order denying the motion for JNOV and the motion for new trial because Dow’s notice of appeal only covered these issues. Our task cannot be reduced so easily. Fed.R.App.P. 3(c) requires appellants to designate the judgment or order to be appealed. In its second notice of appeal, Dow stated that it was appealing from the “judgment entered in this action,”
and
from the denial of the motion for JNOV and motion for new trial. Notices of appeal should be liberally construed.
See Ingraham v. United States,
B. Dr. Teitelbaum’s Testimony
Dow strongly attacks the plaintiff's principal witness, Dr. Teitelbaum. It argues that the trial court erred in admitting his testimony which was the only evidence that *1431 2,4-D caused Greenhill’s Hodgkin’s disease.
Dr. Teitelbaum’s qualifications are substantial. He is a medical doctor and certified in toxicology.
As to his preparation for this case, Dr. Teitelbaum testified that:
I’ve reviewed the medical records of Mr. Greenhill, as much as we have been able to get. I have reviewed his deposition. I have reviewed the medical literature on the subject. I’ve looked at the slides. I had the slides looked at by colleagues ....
Dr. Teitelbaum’s testimony was extensive. He first testified about the difficulty of diagnosing Hodgkin’s disease, both in general and in this case.
Dow raises a number of objections about Dr. Teitelbaum’s testimony. We will address each in turn.
The trial court’s admission or exclusion of expert testimony will not be reversed on appeal unless the district court’s action was “ ‘manifestly erroneous.’ ”
Koonce v. Quaker Safety Prods. & Mfg. Co.,
1. Specialization
First, Dow complains that Dr. Teitelbaum was not qualified to render an opinion because he was not a specialist in any relevant field. Dow preserved this objection.
See
2. Adequate Basis
Dow next objects to Dr. Teitelbaum’s testimony on the grounds that he had no adequate basis for his opinion. Specifically, Dow argues that Dr. Teitelbaum’s opinion was inadmissible because: (1) he never examined Greenhill personally, and (2) his opinion was based solely on information supplied by counsel. Dow’s overall objection to Dr. Teitelbaum’s qualifications properly preserved this issue.
The Federal Rules of Evidence require that an expert’s opinion be based on information “of a type reasonably relied upon by experts in the particular field....” Fed.R.Evid. 703. In making this determination, the trial court should defer to the expert’s opinion of what data they find reasonably reliable.
Greenwood Utils. Comm’n v. Mississippi Power Co.,
Our review of this error is hampered because neither the parties nor the court framed the issue in these terms. Indeed, the district court overruled Dow’s objection without comment.
The determination of whether an expert meets the requirements of Fed.R.Evid. 703 must be made on a case-by-case basis.
Soden v. Freightliner Corp.,
Dow’s first objection, that Dr. Teitelbaum never personally examined Mr. Greenhill, fails to hit its mark. A personal examination of the person or object of the expert’s testimony is not required under Fed.R.Evid. 703. In
Sweet v. United States,
Dow’s second objection, that Dr. Teitelbaum relied on information supplied by plaintiff’s counsel in reaching his conclusion, also fails. This does not require the exclusion of the expert’s testimony.
See Gideon v. Johns-Manville Sales Corp.,
3. Scientific Literature
Dow next argues that Dr. Teitelbaum’s testimony should have been exclud
*1433
ed because the scientific articles on which he relied were published after Mr. Green-hill’s exposure and, thus, could not form the basis of liability for inadequate warnings. This argument fails for two reasons. First, Dow never objected to Dr. Teitel-baum’s testimony on these grounds; any error was waived.
See
Fed.R.Evid. 103(a). Further, while the scientific articles that post-dated Greenhill’s exposure may not have been relevant to the adequacy of warnings, they were admissible on the issue of causation.
Cf. Challoner v. Day & Zimmermann, Inc.,
Dow also complains in its brief that the scientific literature upon which Dr. Teitelbaum relied “dealt with disease entities which Greenhill did not have” or were “wholly irrelevant.” During Dr. Teitelbaum’s direct examination, Dow’s counsel objected to the discussion of two scientific articles detailing neurological damage suffered by patients exposed to 2,4-D on the grounds that plaintiffs alleged no neurological illness.
5
Plaintiffs respond that the neurological symptoms described in these articles were similar to those experienced by Greenhill. Dr. Teitelbaum did not discuss any such link between the neurological studies and Greenhill’s symptoms. Nevertheless, we cannot conclude that the admission of this evidence warrants reversal.
See Petty v. Ideco, Div. of Dresser Indus., Inc.,
4. Cause of Hodgkin’s Disease
Dow next argues that Dr. Teitelbaum’s causation testimony was inadmissible because he admitted that the cause of 95% of all Hodgkin’s disease cases is unknown.
5. “One-hit” Theory
Dow also objected to the admission of Dr. Teitelbaum’s testimony on the grounds that his “one-hit” theory of causation was “specious.” This theory suggests that one molecule of carcinogen, in the right place and at the right time, can cause cancer.
Even assuming that this error was preserved, the absence of a scientific consensus on a given theory does not affect the admissibility of an expert’s opinion.
An expert’s opinion need not be generally accepted in the scientific community before it can be sufficiently reliable and probative to support a jury finding.... What is necessary is that the expert arrived at his causation opinion by relying upon methods that other experts in his field would reasonably rely on in forming their own, possibly different opinions, about what caused the patient’s disease.
Osburn v. Anchor Laboratories, Inc.,
6.Dow Study
Finally, Dow objects to Dr. Teitelbaum’s testimony on the grounds that he was permitted to testify that 2,4-D contained impurities and that Dow’s failure to report these impurities violated EPA regulations. Using a confidential Dow report, Dr. Teitel-baum testified that the 2,4-D produced at Dow’s plant contained impurities,
Experts are entitled to rely on studies in forming their opinions.
See, e.g., Mannino v. International Mfg. Co.,
More troublesome, however, was Dr. Teitelbaum’s testimony implying that Dow violated the law by not reporting the impurities to the EPA. This testimony was admitted even though these questions were outside the doctor’s expertise and there was no evidence that he knew (1) whether the EPA had reporting requirements or (2) whether Dow complied with them. This was error, but we hold it to be harmless. Dow has not shown that Dr. Teitelbaum’s testimony was either incorrect or known by Dr. Teitelbaum to be incorrect.
7.Recent Decisions of this Court
To support its argument that Dr. Teitel-baum’s testimony should have been excluded, Dow relies on two recent decisions of this court,
Eymard v. Pan Am. World Airways (In re Air Crash Disaster),
8.Conclusion
Based on our review of Dr. Teitelbaum’s testimony and all of Dow’s objections, we conclude that the district court did not abuse its discretion or commit manifest error in admitting his testimony.
C. Testimony of Kier and Tipton
Dow next complains of the testimony of Andrew Kier and Paul Tipton, former United States Forest Service employees, who testified about the “hack and squirt” operations. The trial court’s decision to admit lay opinion testimony will only be reversed for an abuse of discretion.
Scheib v. Williams-McWilliams Co.,
Dow objected to the admission of this evidence on the grounds that it was irrelevant, and because neither witness had seen Mr. Greenhill perform the hack and squirt operation.
The trial court’s admission of this testimony was not error. Both witnesses testified generally about how hack and squirt operations were performed. Each was testifying from his own knowledge and spoke to his own observations. See generally E. Cleary, supra, § 10.
D. Motion for New Trial
Dow, in its next complaint, reveals more about the gamesmanship in litigation than it does about judicial error. It complains about the trial court’s denial of its motion for new trial on the basis of newly-discovered evidence.
7
Dow claims that Dr. Teitelbaum testified falsely at trial about knowing a man named Joseph Moss. The facts surrounding this issue are somewhat confused. It seems that before Dr. Teitelbaum’s deposition, his assistants collected three boxes of medical records regarding this case for the deposition.
At trial, Dow’s counsel produced exhibit 2 and asked Dr. Teitelbaum if he had relied on those records. Dr. Teitelbaum apparently became confused when he saw the Moss records contained in exhibit 2 and stated that he did not know Joseph Moss.
Eventually, the trial court intervened. In response to the judge’s questions, Dow’s counsel admitted that he realized during the deposition that Dr. Teitelbaum’s assistants had mistakenly included Moss’ medical records, which had nothing to do with the Greenhill case.
We will not overturn the district court’s refusal to grant a motion for new trial on the basis of newly discovered evidence absent a clear abuse of discretion.
Osburn v. Anchor Laboratories, Inc.,
Applying this standard, the district court properly denied Dow’s motion. That Dr. Teitelbaum erroneously claimed not to know Joseph Moss could not have affected the outcome of the trial. Dow’s counsel knew of the source of the mistake from an early point in the litigation. In his cross-examination of Dr. Teitelbaum, Dow’s counsel effectively revealed that the doctor testified in hundreds of trials.
E. Motion to Transfer Venue
Dow’s third ground of error complains of the district court’s denial of its motion to transfer venue to Oregon under 28 U.S.C. § 1404(a) (1982).
After reviewing the record, we conclude that the district court did not abuse its discretion in denying Dow’s § 1404(a) motion. To begin, the plaintiff is generally entitled to choose the forum.
See Menendez Rodriguez v. Pan Am. Life Ins. Co.,
Dow, relying on
Trivelloni-Lorenzi v. Pan Am. World Airways (In re Air Crash Disaster),
Dow’s reliance on
In re Air Crash
is misplaced. In that case this court required district courts in denying a motion to
dismiss
on the grounds of
forum non conve-niens
to file a written order or to make a statement on the record explaining its denial.
See
F. The District Court’s Actions
In its final ground of error, Dow charges that the district court’s “overall supervision and management of this case deprived Dow of a fair trial.” In this portion of its brief, Dow simply catalogues a number of adverse rulings by the trial court. We have examined the record and, while not entirely happy with what we see, we find no basis *1437 for this charge. The trial was fair although not perfect.
G. Dow’s Reply Brief
Dow raises four additional grounds of error in its reply brief. We may not review arguments raised for the first time in the appellant’s reply brief.
Light v. Blue Cross & Blue Shield, Inc.,
The judgment of the district court is AFFIRMED.
Notes
. Mr. Greenhill died after the suit was filed and the present parties were substituted.
. To positively diagnose Hodgkin’s disease, a pathologist must find a “Reed-Sternberg” cell in a tissue analysis.
. Dr. Teitelbaum is certified by the American Board of Toxicology.
. Dow, in its motion for summary judgment, also argued that Dr. Teitelbaum’s testimony lacked a sufficient basis because he did not know of the extent or duration of Greenhill's exposure to 2,4-D. Although Dow raised this objection in its motion for summary judgment,
. Dow’s counsel also objected when another study linking cancer to exposure to phenoxya-cetic acids was discussed. Dow objected on the grounds that such acids might differ from 2,4-D, and that the doctor’s inference based on this study was speculative.
. Tordon 101 is the brand name of the herbicide whose main ingredient is 2,4-D.
. Dow also contends that the district court erred in overruling their motion for JNOV for the same reasons. A motion for JNOV should be granted when there is insufficient evidence to support the jury’s verdict.
See Kendrick v. Illinois Cent. Gulf R.R.,
